Endometrial responses to hormone replacement therapy: the bleeding pattern
نویسندگان
چکیده
منابع مشابه
Endometrial expression of steroid receptors in postmenopausal hormone replacement therapy users: relationship to bleeding patterns.
BACKGROUND Mechanisms of menopausal hormone replacement therapy (HRT)-related bleeding, undoubtedly mediated through endometrial steroid receptors, are poorly understood. We aimed to determine the steroid receptor expression in HRT-exposed endometrium in relation to disturbances of bleeding patterns. METHODS Prospective observational study in a tertiary referral menopause clinic in Western Au...
متن کاملHormone replacement therapy in postmenopausal women: endometrial hyperplasia and irregular bleeding.
BACKGROUND The decline in circulating oestrogen around the time of the menopause often induces unacceptable symptoms that affect the health and well being of women. Hormone replacement therapy (both unopposed oestrogen and oestrogen and progestogen combinations) is an effective treatment for these symptoms. In women with an intact uterus, unopposed oestrogen may induce endometrial stimulation a...
متن کاملManagement of bleeding problems with hormone replacement therapy.
It is well established that all non-hysterectomised women taking oestrogen replacement therapy should receive additional progestogen to reduce the incidence of endometrial hyperplasia1–3 and cancer.4 Progestogens are either added cyclically on a monthly (sequential), or 3monthly basis (tricyclic) or continuously (period-free or no bleed). Alternative combinations such as bimonthly,5 6monthly6 a...
متن کاملHormone therapy after endometrial cancer.
Endometrial carcinoma is often listed in data sheets as an absolute contraindication to hormone replacement therapy. However, observational studies have not shown an increased rate of recurrence or mortality. Thus, it is often used after stage I or II disease. Alternatives such as progestogens, tibolone, raloxifene, venlafaxine and herbal preparations are examined. The use of progestogens is un...
متن کاملHormone replacement therapy.
HRT is indicated for the treatment of moderate ▪ to severe vasomotor and urogenital symptoms associated with menopause. HRT is not recommended for primary prevention of ▪ disease because of increased risk of other adverse events. The use of HRT increases the risk of stroke, venous ▪ thromboembolism (VTE) and gall bladder disease and combined oestrogen progestogen therapy is also associated with...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1996
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/11.3.503